Biphasic Dose Response in Low Level Light Therapy (Includes Update)

This review paper covers the current theory on basic mechanisms of laser therapy and discusses the effects of different dosing strategies. Cytochrome c is identified as the primary absorber of light in the near infrared leading to cellular changes related to ATP, NO and ROS levels. Different doses of laser therapy are shown to either stimulate or inhibit multiple metabolic and cell signaling pathways.

ORIGINAL STUDY: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2790317/ Published: Dose-Response. 2009; 7(4): 358–383. doi: 10.2203/dose-response.09-027.Hamblin

UPDATE: Update on review paper for bi-phasic dose response. Published: Dose-Response. 2011; 9: 602-618. doi: 10.2203/dose-response.11-009.11-009.Hamblin