Low-Level Laser Therapy Acts Differently on mRNA Expression of Anti- and Pro-Inflammatory Mediators in Collagenase-Induced Tendinitis in Rat

A rat model of induced tendonitis was used to evaluate the effect of laser therapy on inflammatory signaling. The laser group had significantly lower mRNA for IL-6, COX-2 and TGF-β than control animals in both acute and chronic phases. Laser therapy significantly reduced mRNA TNF-α only at the chronic phase. Laser therapy is effective for the reduction of mRNA expression for pro-inflammatory mediators.

Study Title: Low-level laser therapy (LLLT; 780 nm) acts differently on mRNA expression of anti- and pro-inflammatory mediators in an experimental model of collagenase-induced tendinitis in rat